Sunday, March 22, 2020

COVID-19: Things to consider before you panic.


With China showing no new cases over the weekend, I thought it might be useful to go through a few things so you can continue living free of panic. I've spent a huge amount of time reading lots of actual science and CDC reports to get these nuggets in one spot for you, so if you have any additional questions, please let me know. I put a few of the articles below the list if you want to read for yourselves. Things to keep in mind:

1.     Pandemic just means the condition is world-wide. So even though COVID-19 is a pandemic, so are ALLERGIES, for example. “Epidemic” is a title that is more reflective of a deadly condition. A death rate of 7.3% defines a condition as “epidemic”. Flu falls just short of this at 7.1% this year. Global death rate of COVID-19 is 4.1%. USA death rate of COVID-19? 1.4%.
2.     The Peak of Disease in the USA still looks like it was on March 9th, according to the CDC reports of CONFIRMED CASES. This was 3 weeks after the first cases appeared, which reflects the 14 day incubation period. We are now further out than that by nearly 2 more weeks. Continue to be careful that you aren’t reading information on websites or the news that are using estimates because they make the data look like it’s still rising when the reported cases to the government (which hospitals are required to report) do not support that.
3.     More than 80% of the cases reported in China were MILD. This is the same observation made here. It probably also speaks to the likelihood that most of us have already been infected, just never showed signs that were concerning.
4.     In the USA, 508 people are sick enough to be hospitalized right now. So while there are over 15,000 cases UNCONFIRMED to date in the USA, that means around 3% of people showing symptoms are ending up in the hospital.
5.     There are nearly nine thousand beds in intensive care units in Texas ALONE. So even if all 508 COVID-19 patients hospitalized right now in the USA were here in Texas, we would not be overrun.
6.     Of those ending up in the hospital, 80% of the deaths are in people older than 65 WITH UNDERLYING MEDICAL CONDITIONS. These are the folks that need to stay home without question and you should not go visit them because it puts them at risk.
7.     Population density plays a huge role in the spread. High density populations can expect higher spread. Korea, China and Italy have some of the highest population densities in the world. Korea is at 1,366 people per square mile. Italy is at 532 people per square mile. China is at 397 people per square mile. In the Wuhan Providence where the virus originated, it’s 3,200 people per square mile. In the USA? 94 people per square mile. The range is large however, as in New York, it’s 28,000 people per square mile. No wonder the virus spread so fast there.
8.     The first clinical trial is active already. There are 4 drugs being considered and early reports indicate they are working. One of them, Chloroquine, is a tablet that people who are traveling to places where malaria is prevalent take to prevent infection. It’s a pill they take once a week. Chloroquine changes the ability of the young malaria parasites to digest food properly, and so they die. Researchers showed last week that chloroquine stops the Coronavirus from thriving in the cells they were infecting and stops the Coronavirus from infecting new cells. This was NOT done in animals or humans, but in a cell line. Still, the results are promising enough that major pharmaceutical companies are donating their Chloroquine stocks to the government for use in patients fighting COVID-19.
9.     Limitation: Testing is still not wide-spread, so the confirmed cases may be low. However, as over 80% of those with the virus probably don’t even realize they had it, there is no way to get a true estimate of who was infected. It is likely then that the death rate is even lower than what I calculated above.
10.  Caution: Continue to follow the CDC guidelines for how to operate. Wash your hands because soap and water for 20 seconds kills the virus. Stay home when you are sick so you don’t infect anyone else. Do not visit those at high risk because you could be carrying the virus (but are fighting it successfully with your good immune system and you probably didn’t even know you had it!). Hug those living with you often.

Morbidity and Mortality Weekly Report on COVID-19

The in vitro data that prompted USA off-label use of Chloroquine and H-Chloroquine

Details of the 4 drugs in the Solidarity Trial by WHO

2 comments:

  1. Can you explain where you are getting your flu mortality rate from? I haven’t seen numbers any where for the rate of 7.1%. Everything I have seen is .1% from CDC and others from scientific communities.

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  2. I sure will. Hang on, I'll put that in the next blog. Coming soon.

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